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” He and Munakata think that gradual changes in the way in which the DNA is stored could lead on to some lack of fertility as Females age. If that is so, their study could pave the way in which for improved cure and analysis of fertility troubles.
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Utilizing the GCRLE grant, Munakata and Namekawa will appear extra carefully at how oocytes are genomically primed and stored for later on use. They are going to examine the position of the chromatin remodeler in oocyte survival and fertility.
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Munakata and Namekawa will Look at mice with usual and mutated versions of the chromatin remodeler. Given that the mice mature and mature, they can observe whether the presence or absence of the protein triggers variations during the arrangement of DNA spools within the animals’ oocytes. And they're going to monitor irrespective of whether this, in turn, alters the pattern of gene expression after some time.
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